Morgan Tuck scored 16 of her 18 points in the first half and the three-time defending national champions (12-0, 2-0 American) had five players in double figures.
Freshman Katie Lou Samuelson had 14 points while Breanna Stewart added 12 points and nine rebounds.
Tuck hit her first four shots from the floor and UConn held Tulsa without a basket for the final five minutes of the first quarter, part of a 15-0 run that put the game away early. A jumper by Stewart put the Huskies up 49-18 at the half.
Ashley Clark had 10 points for Tulsa (5-9, 2-1), which was coming off a pair of two-point wins to open its conference season.
After the game Bob Rumbold caught up Chong to break down her performance.